The downregulation of FTH1 expression in cancer cells both in vitro and in vivo resulted in increased vulnerability of glioma U251, sNF96.2, and breast cancer MCF‐7 cells to chemotherapy [4, 10]; based on these reports, we hypothesized that downregulation of FTH1 in NSCLC cells could provide a mechanism to increase the chemotherapeutic sensitivity of lung cancer by eliminating the protective functions of FTH1. The gene discussed is FTH1; the disease is central nervous system cancer.