Adiponectin has been shown to modulate neutrophil activity by inhibiting chemotaxis, reducing oxidative burst via NADPH oxidase inhibition [76], and decreasing neutrophil apoptosis through AMPK activation and p38 MAPK inhibition [77], which in turn could explain how adiponectin potentially protects tissues and improves survival in sepsis. The gene discussed is ADIPOQ; the disease is Sepsis.