This could provide an additional mechanism through which adiponectin exerts its anti-inflammatory role in sepsis, since it is known that macrophages play a pivotal role in infection and inflammation, including sepsis, and that in the early stages of sepsis, pro-inflammatory factors encourage macrophages to polarize into M1 phenotype, in an uncontrolled manner that evolves into a cytokine storm, exacerbating inflammation and tissue damage. Here, ADIPOQ is linked to Sepsis.