ADIPOR1 and injury: Studies in LPS-induced septic mice have shown that AdipoR1 is downregulated in sepsis-associated encephalopathy (SAE), contributing to neuronal damage and cognitive decline, while activation of AdipoR1 by a receptor agonist (AdipoRon) restores AMPK signaling, reducing neuroinflammation and protecting against SAE-induced brain injury [56].