Differential expression analysis revealed minimal transcriptional variance between relapsed and diagnostic tumors, observing 709 up- or down-regulated genes (FDR < 0.05, |Log2FC | >0.5) including enrichment for genes with established potential in lymphoma in rrDLBCL such as CELSR2 (Log2FC = 0.51, FDR = 1.95e-5), MYC (Log2FC = 0.55, FDR = 2.06e-4), CD274 (PD-L1; Log2FC = 0.52, FDR = 3.19e-3), and USP6 (Log2FC = 0.76, FDR = 4.25e-3; Fig. 3A). This evidence concerns the gene CD274 and lymphoma.