OTUD6B suppressed hepatocellular carcinoma metastasis, involving a feedback loop consisting of OTUD6B, pVHL, and HIF-1α [6]; CircPTPN12 bolstered the assembly of the PDLIM2/OTUD6B complex and inhibited hepatocellular carcinoma progression by PDLIM2/NF-κB pathway [7]. Here, VHL is linked to hepatocellular carcinoma.