To address the effect of VEGFR-3 inhibition by SAR131675 on TLR7/MyD88/IFN-α signaling pathway, we evaluated toll-like receptor 7 (TLR7), myeloid differentiation primary response 88 (MyD88), and IFN-α expression in the resiquimod-induced LN. The gene discussed is FLT4; the disease is lobular neoplasia.