Moreover, we observed that low expression of STUB1 was negatively correlated with high GOT2 expression in most human BCa tumors and STUB1 overexpression or GOT2 knockdown inhibited tumor growth, while co-overexpression of STUB1 and GOT2 knockdown enhance this effect, demonstrating a dominant role of STUB1-GOT2 axis in controlling of in vivo tumor growth. This evidence concerns the gene GOT2 and neoplasm.