GOT2 and neoplasm: We next investigated the effect of the STUB1-GOT2 axis on BCa cell growth and survival in vivo xenograft tumor model derived from T24 cells after overexpression of STUB1 or shRNA-based knockdown of GOT2 or both and found that STUB1 overexpression or GOT2 knockdown inhibited tumor growth, while co-overexpression of STUB1 and GOT2 knockdown enhance this effect (Fig. 5E–G),