It could be shown that METTL3 inhibition causes selective leukaemia cell lethality and prolonged survival in multiple AML models, where it led to depletion of LSC-enriched cell fractions in vitro and in vivo, indicating that AML stem cells are particularly vulnerable to loss of m6A methylation activity [83]. The gene discussed is METTL3; the disease is acute myeloid leukemia.