Thus, METTL3 and YTHDF2 cooperate to enforce a leukemia-favourable transcriptome: METTL3 writes m6A marks on key growth/self-renewal transcripts to facilitate their expression, while YTHDF2 “reads” m6A on differentiation-inducing transcripts to target them for degradation, collectively preserving the LSC phenotype. The gene discussed is YTHDF2; the disease is leukemia.