KMT2A and acute myeloid leukemia: As detailed in this review, key epigenetic disturbances in AML include widespread DNA hypermethylation (often driven by DNMT3A, TET2, or IDH mutations), altered histone modification patterns (due to lesions in MLL/KMT2A, ASXL1, and others), disrupted higher-order chromatin structure (from Cohesin mutations), and leukemogenic RNA modifications.