Men1Δ/Δ increased the number of F4/80highCD11bint KCs but had no significant effect on F4/80+CD11bhigh monocyte-derived macrophages (moMACs) (18) (Figs. 1E and S1I), suggesting that menin predominantly impacts the regeneration of KCs rather than the recruitment of moMACs during the progression of liver fibrosis. This evidence concerns the gene MEN1 and Hepatic fibrosis.