Characteristics including left-sided colitis/proctitis, fCal ≤250 μg/g, C-reactive protein [CRP] ≤6 mg/L, baseline MMS, endoscopic subscore (ES) = 2, SF subscore <3, and no prior biologic or tofacitinib failure were significantly associated with DC at W12 in the univariable analysis (Table S2). The gene discussed is CRP; the disease is colitis.