ACSS2 and neoplasm: Histone crotonylation predominantly enriches in promoter and CDS regions, activating gene transcription.[21, 22, 23] For example, Histone H4 lysine crotonylation could enhance the expression of immunogenic retroelements to elicit anti‐tumor immune response.[22] Similarly, both H3K9cr and H3K27cr have been shown to promote gene expression.[26, 27] Our ChIP‐seq and ATAC‐seq data suggest that ACSS2‐mediated H4K12cr enhances CLDN7 expression by increasing chromatin accessibility and transcriptional activity in intestinal epithelium.