TNF‐α, a well‐known pro‐inflammatory cytokine, was implicated in IBD progression through various mechanisms.[55, 56, 57] Herein, our study demonstrated that TNF‐α inhibits FTO to destabilize ACSS2 mRNA by increasing its m6A modification, leading to a decline of histone Kcr levels. The gene discussed is TNF; the disease is inflammatory bowel disease.