Given that Kcr homeostasis is coordinately regulated by three key elements: crotonyl‐transferases (writers), decrotonylases (erasers), and substrate availability (crotonyl‐CoA), we conducted transcriptomic analysis of these regulatory components in a public IBD cohort (GSE59071).[28] Significant reduction of several enzymes for crotonyl‐CoA synthesis was identified in IBD patients, among which ACSS2 was downregulated in both human and murine inflamed intestinal tissues (Figure 1B; Figure S1D, Supporting Information). The gene discussed is ACSS2; the disease is inflammatory bowel disease.