To explore whether ACSS2 is involved in IBD progression, Acss2 intestinal epithelium conditional knockout mice (Vil1‐cre, Acss2fl/fl; Acss2CKO) and control mice (Acss2fl/fl) were generated and confirmed by genotyping (Figure S2A,B, Supporting Information) and immunoblotting (Figure2A,B). Here, VIL1 is linked to inflammatory bowel disease.