CLDN7 and colitis: Interestingly, NaCr could alleviate colitis symptoms (Figure S8A–G, Supporting Information), increase plasma crotonyl‐CoA level (Figure S8H, Supporting Information) and upregulate H4K12cr and CLDN7 protein levels in Acss2fl/fl mice (Figure S8I,J, Supporting Information), but exhibited no obvious effect on Acss2CKO mice (Figure S8, Supporting Information).