Additionally, in another screening of potentialPXR antagonists,compound 100* has been identified as a kinase (RAF1)and PXR antagonist through its interaction with the PXR LBD in colonLS174T cancer cells; however, it exhibited partial agonist activityin phenotypically differentiated HepaRG cells. Other compounds have been identified to inhibit PXR allosterically.−, Here, NR1I2 is linked to cancer.