Curiously,SJPYT-195, in this way, indirectly reduced PXR protein levels in colonSNU-C4 cancer cells. Thus, ligand-unknownE3 ligases UBR5, RBCK1, FBXO44, and TRIM21, which mediate PXR ubiquitination,require further investigation. A recentlydiscovered PXR PROTAC (compound 38*) conjugated withVHL ligand (VH032) has demonstrated an effective degradation profileof PXR. However, a comprehensive understandingof how these molecules suppress all PXR target genes remains unknown. This evidence concerns the gene NR1I2 and cancer.