As the host’s second circadian clock, it also exhibits diurnal oscillation characteristics and has garnered attention in the field of cardiovascular disease research.7,8 The diurnal oscillation of the gut microbiota plays a crucial role in the host’s physiological processes, especially in maintaining the metabolic balance of nutrients.9,10 Metabolic imbalance is a fundamental feature of ASCVD.11 The gene discussed is CLOCK; the disease is atherosclerosis.