According to Western blot and PCR results, after VPA + Niclo treatment, the increase in E‐Cadherin levels and the decrease in β‐Catenin, Fibronectin, Vimentin, and N‐Cadherin levels at both protein and gene levels indicated that combination therapy may be useful in preventing the EMT process in lung cancer cells. This evidence concerns the gene CDH2 and lung carcinoma.