In the study, polymorphism data of five single nucleotide polymorphisms of the DNA repair gene XRCC1 (XRCC1 399, XRCC1 194, XRCC1 206, XRCC1 632, XRCC1 280) from the population of northern India, along with data on smoker status, were considered as inputs to the proposed ensemble model to predict the risk of individual susceptibility to lung cancer. The gene discussed is XRCC1; the disease is lung cancer.