VEGFA and Infertility: In addition, while subclinical/undiagnosed endometriosis as an underlying factor responsible for unexplained infertility is not a novel observation per se, the unexpected combination of VCAM-1, VEGF, sICAM-3, angiopoietin-1, and sTie-2, which are all proteins that have been associated with endometriosis, is novel and compelling; however, a causal association between these proteins, endometriosis, and UI requires more study, and the exclusion of other mechanisms that are out of the scope of this study.