In addition, the essential oil exhibited pronounced antitumor effects, particularly against HCT116 colorectal cancer cells, in which it induced apoptosis through modulation of Bax, Bcl-2, and caspase-3 expression, and triggered G1-phase cell-cycle arrest via downregulation of Cyclin D and p-AKT. This evidence concerns the gene CASP3 and colorectal cancer.