IL6 and hyperinsulinemic hypoglycemia, familial, 4: Additionally, reduced IL-6 production can occur due to genetic factors (e.g., IL-6 gene polymorphisms), specific haplotypes more prevalent in certain populations (such as some Asian groups) [217], IL-6 deficiency [218], or treatment with IL-6 inhibitors [219], which may interfere with diagnostic or prognostic assessments based on IL-6 levels.