NR3C1 and psoriasis: Defective glucocorticoid signaling contributes significantly to the pathogenesis of psoriasis and arises from a broad dysregulation of the skin’s local steroidogenic machinery, including reduced expression of key enzymes (CYP11A1, CYP17, 11βHSD1, 11βHSD2), transport proteins (StAR, MLN64), and even the glucocorticoid receptor itself.