CNP and mucopolysaccharidosis type 4A: Similarly, a previous study by Rintz et al. (2023) showed that AAV8-mediated C-type natriuretic peptide (CNP) expression induces bone growth in MPS IVA mice, which correlates with increased chondrocyte proliferation, along with a more columnar chondrocyte organization and reduced chondrocyte size compared to that observed in untreated MPS IVA mice [132].