Using the DHT rat model of PCOS, Pruett et al. evaluated the role of oxidative stress in subcutaneous, retroperitoneal, and mesenteric white adipose tissue (WAT) depots and showed that cytosolic SOD 1 and mitochondrial SOD2 proteins were decreased, but catalase was increased in the WAT from the PCOS model compared to controls [33]. The gene discussed is SOD2; the disease is polycystic ovary syndrome.