Li et al. used a DHEA-induced rat model of PCOS to evaluate the role of NADPH oxidase 4 (NOX4), which is highly expressed in ovaries from this model [81] and found that using lentiviral-mediated shRNA against NOX4 reduced oxidative stress in the ovaries, as measured based on 4-hydroxynonenal and MDA, and increased SOD and glutathione peroxidase activities [81]. The gene discussed is SOD1; the disease is polycystic ovary syndrome.