As mentioned above LncRNAs can alter gene expressions by binding with proteins, DNA, RNA individually, or with their combination, and MALAT1 has been shown to alter the histone 3 lysine 27 trimethylation levels of a gene by directly binding with histone methyl transferase Ezh2 in prostate cancer cell lines and HRECs incubated in high glucose [35,38]. This evidence concerns the gene EZH2 and Familial prostate cancer.