This is the first study to investigate the relationship between the PNPLA3 rs738409, TM6SF2 rs58542926, GCKR rs1260326 and rs780094, MBOAT7 rs641738, HSD17B13 rs72613567, and MTARC1 rs2642438 polymorphisms in the Brazilian population with MASLD and liver fibrosis. The gene discussed is HSD17B13; the disease is Hepatic fibrosis.