ERN1 and glioblastoma: The urea-based compound Z4P was shown to diminish the migratory capacity of glioblastoma cells (U251, RADH85, and RADH87), arrested IRE1 phosphorylation in U87 cells, reduced the burden of xenograft tumors in mice, prolonged relapse-free survival, and sensitized glioblastoma to temozolomide [228].