EIF2AK3 and neoplasm: In pancreatic BxPC3 cells stressed by tunicamycin or TG, GSK2656157 suppressed PERK/eIF2 phosphorylation, decreased ATF4 and CHOP levels, and changed the expression of UPR-associated genes, while its oral administration inhibited the growth of pancreatic and multiple myeloma xenografts in mice accompanied by impaired tumor angiogenesis [185].