HSPA5 and central nervous system cancer: Abnormally elevated levels of GRP78 correlated with stronger aggressiveness, lower overall survival, increased invasion and metastasis, and low sensitivity to anti-cancer agents in patients with HCC [73,95,96], gastric cancer [97], gliomas [98], prostate cancer [99], PDAC [100], lung cancer [101,102], and HNSCC [103].