HIF1A and neoplasm: Disruptions in the functioning of these factors are associated with many diseases; for example, hyperactivation of NF-κB is observed in autoimmune diseases and cancer, mutations in the TP53 gene occur in more than half of cancer cases, excessive HIF-1α activity promotes tumor growth under hypoxic conditions, and STAT3 imbalance is detected in malignant neoplasms and chronic inflammation [8,9].