RELA and ischemic stroke: Thus, the RelA subunit of the activated p50/RelA dimer plays a key role in the onset of neurodegenerative processes induced by ischemic strokes, as well as glutamate or beta-amyloid toxicity, while another c-Rel subunit in activated NF-κB dimers determines the resistance of neurons to brain strokes [83,97,98,99,100].