Hyperandrogenemia plays a major role in the pathogenesis of NAFLD/MASLD in PCOS through an extended half-life of low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) via inhibited LDL-receptor expression leading to elevated concentrations of LDL, triglycerides and increased IR [39]. The gene discussed is LDLR; the disease is polycystic ovary syndrome.