TMC1 and hearing loss disorder: To date, over 90 mutations in TMC1 have been associated with various forms of hearing loss, including DFNA36 (autosomal dominant non-syndromic sensorineural deafness 36), DFNB7/11 (autosomal recessive non-syndromic sensorineural deafness 7/11), and early-onset presbycusis [11].