Herein, we report the differential expression of NGF, BDNF, and related receptors between myopia and high myopia, and their association with NO/nitrites/iNOS/NOX1/4, KEAP1/NRF2, and some epigenetic factors (HDMT3α, HD1), as observed from studies on aqueous and myopic LEC. Here, BDNF is linked to myopia.