The association between higher PD-L1 expression levels in TP53 mutated tumours may be due to the fact that TP53 encodes a protein that increases miR-34 expression, an miRNA involved in the attenuation of PD-L1 expression through its binding to the 3′ untranslated regions of PD-L1 mRNA in models of NSCLC [44,53]. The gene discussed is CD274; the disease is neoplasm.