The results showed that compared with the normal group, the expression of DNMT1 mRNA in the model group rats was high; compared with the model group, the expression of DNMT1 mRNA in the drug group rats was significantly reduced, suggesting that Wutou decoction may inhibit the expression of DNMT1 mRNA, inhibit rat synovial hyperplasia, and alleviate arthritis symptoms [70]. The gene discussed is DNMT1; the disease is arthritic joint disease.