CRBN and Miyoshi myopathy: Median levels of CRBN at LD initiation were 247 pg/mL (range, 0–9760 pg/mL), at the time of best response status 142.5 pg/mL (range, 0–9940 pg/mL), and in patients with relapse/refractory MM to LD regimen 298 pg/mL (range, 0–9840 pg/mL), while in normal controls CRBN levels were almost undetectable with a median value of 0 pg/mL (range: 0 to 580 pg/mL) (Figure 1).