From available data in bone marrow samples, CRBN expression reversely correlated with (ISS) [9,14], serum beta-2-microglobulin (B2M), and serum albumin [14], while another study observed that increased levels of CRBN expression were associated with higher B2M (r = 0.66, p = 0.001) of newly diagnosed MM patients [15]. The gene discussed is B2M; the disease is Miyoshi myopathy.