POU5F1 and hepatocellular carcinoma: The former has as a target p27/Kip1 in HCC, promoting its overexpression, the second targets Rb-binding protein 4 (RBBP4), promoting the expression of POU class 5 homeobox 1 (POU5F1), while the third is implicated in miR-338 and low-density lipoprotein receptor-related protein 6 (LRP6) axis, enhancing HCC progression [112,113,114,116].