Moreover, TME-fibroblasts are activated (cancer-associated fibroblasts (CAFs)) in highly malignant HCC, with an increased metastatic behavior via HCC-derived miR-1247-3p that alters the expression (decrease) of Beta-1,4-Galactosyltransferase 3 (B4GALT3) [109]. The gene discussed is B3GALT4; the disease is hepatocellular carcinoma.