EV-cargoes such as miRNAs and other non-coding RNAs (lncRNAs, circular RNAs (circRNAs), etc.)have a crucial role in HCC proliferation, progression, invasion, migration, and lastly metastatic dissemination via stimulating several signaling pathways such as PI3K/AKT and MAPK [104,105]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.