Xu et al. have observed that high expression of LDH isoform B (LDHB) in tumor samples of patients from TCGA database was associated with diminished immune cell infiltration and cytotoxic T cells dysfunction, while low LDHB expression was associated with reduced tumor cell proliferation and ATP production, improved immune cell infiltration, and better response to immunotherapy. The gene discussed is LDHB; the disease is neoplasm.