SLC22A8 and chronic kidney disease: Conversely, in a CKD model involving 5/6 nephrectomized rats, Naud et al. reported the decreased mRNA and protein expression of several transporters in brain capillaries including BCRP, MRP2, MRP3, MRP4, OAT3, OATP2, OATP3, and P-gp [67].