As well, the BDNF had a slight tendency to increase in the aqueous (1.441 ± 0.063 vs. 0.933 ± 0.381 pg/mg; AD vs. ctr; p > 0.05; Figure 7C) and to significantly decrease in the vitreous (0.471 ± 0.063 vs. 1.273 ± 0.381 pg/mg; p < 0.05; Figure 7D) of patients with AD-VRD with respect to controls. This evidence concerns the gene BDNF and Alzheimer disease.