MAPT and Alzheimer disease: AD pathogenesis is multifactorial and complex, involving a cascade of interrelated molecular events including extracellular deposition of β-amyloid (Aβ) plaques, intracellular accumulation of hyperphosphorylated tau protein in neurofibrillary tangles, synaptic and neuronal degeneration, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation [3].