Hauspurg et al. [46] in a multicenter prospective observational study on 4103 nulliparous women, found that elevated NT-proBNP levels in early pregnancy (first trimester blood sample) were linked to a notably reduced risk of developing hypertensive disorders during pregnancy (including PE), as well as a lower likelihood of new-onset hypertension within 2–7 years postpartum. This evidence concerns the gene NPPB and hypertensive disorder.