The pathogenic mechanisms associated with the C9ORF72 gene, particularly in the context of C9ORF72-linked amyotrophic lateral sclerosis (ALS), are complex and multifactorial, involving alterations in transcription, RNA foci formation, and the accumulation of toxic proteins such as dipeptide repeats (DPRs) [1]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.