Further, although both models show a similar pattern in terms of electron transport chain protein complex subunit loss and upregulation of glaucoma-related mRNA transcripts CTGF, FN1, and PAI, there is a notable distinction between the two methods, where SFRP1 is significantly upregulated by EtBr but not by UNG1Y147A expression. Here, SERPINE1 is linked to glaucoma.