The SOX4 (SRY-BOX Transcription Factor 4) gene expression is upregulated in CRC, which promotes tumor cell migration and invasion [49], while Zhu et al. (2023) reported that high expression of RPL21 (Ribosomal Protein L21) induces invasion and metastasis in CRC [50]. The gene discussed is SOX4; the disease is colorectal carcinoma.