TNF and obesity due to melanocortin 4 receptor deficiency: In diabetic type 2 humans with high BMI, abdominal obesity, and total obesity have a strong influence on plasma levels of adipokines adiponectin, leptin, and resistin, as the last two increased and similarly change the inflammatory markers high-sensitive C-reactive protein (hsCRP), Tumor necrosis factor-α (TNF-α), and IL-6 (Figure 3) [104].