NFKB1 and cancer: TNBC-derived exosomes enriched with Pyruvate Kinase M2 (PKM2), which is a glycolysis enzyme that promotes cancer metabolism, tumor growth, and immune regulation, polarize macrophages to an M2 phenotype via NF-κB, which silibinin counteracts by upregulating Nrf2 and blocking glycolytic flux [133,137].