Namely, the peptide reduced the expression of many genes (e.g., P2rx6, Gabra3, Grik4, Oprl1, Glra2, Crhr1, Hrh1, Chrm5, Grik1) related to the neurosignaling system and whose expression was not significantly changed by ischemia itself. The gene discussed is GRIK4; the disease is ischemia.