This effect, identified among other things, was not only associated with compensation of the gene-expression profile impaired by ischemia but also with its enhancement of ischemia’s impact on the gene-expression pattern (e.g., S100a9, Gdnf, Bcl2a1, Tlr4, Ccr5, Grin2d, Kcns2, Gabra5, Adra2a, Chrna4) in the striatum (Supplementary Figure S1c). The gene discussed is CHRNA4; the disease is ischemia.