PTEN and neoplasm: Functioning as a tumor suppressor, PTEN exerts its influence by dephosphorylating phosphatidylinositol (3,4,5)-trisphosphate (PIP3), thereby antagonizing the pro-survival and pro-growth signals mediated by the PI3K pathway that regulate a wide range of cellular processes such as growth, proliferation, survival, motility, and metabolism [12,13].