It should be noted that the effector protein of the four pathways common to both asthma phenotypes, ALOX5 or 5-lipooxygenase (5-LO), an enzyme that uses Arachidonic Acid to synthesize Leukotrines (LTs), which induce airway spam, barely showed differences between the two asthma groups in severe and moderate patients but did in mild patients. This evidence concerns the gene ALOX5 and asthma.