ALOX5 and asthma: To conclude, the gene expression of the proteins involved in the signaling pathways of the four asthma trigger proteins was analyzed (Table 4), finding a decrease of all of them in both asthma groups compared to HC, and in those elements common to the signaling pathways defined for AA and NA (RELA; SMAD3; NFATC1, TLR2 and ALOX5), this decrease was greater in the NA patient group (Table 5), in line with what was observed in the four triggers (Table 1).