In another study, an induced pluripotent stem cell (iPSC) derived from the somatic cells of women with PCOS exhibited higher mtDNA copy numbers, biogenesis, and impaired respiration function, along with a higher expression of PGC1α, TFAM, and NRF-1 when compared to non-PCOS-derived iPSCs. Here, NRF1 is linked to polycystic ovary syndrome.