INS and polycystic ovary syndrome: The ones that have are thiazolidinediones (TZDs), specifically pioglitazone and rosiglitazone, which enhance insulin sensitivity, reduce hyperandrogenaemia, and regulate the menstrual cycle in women with PCOS, acting through the activation of the peroxisome proliferator-activated receptor–gamma (PPARγ), a gene responsible for mitochondrial biogenesis.