A reverse translational study conducted on schizophrenia individuals has shown that the overactivation of the MMP9/RAGE pathway can lead to redox dysregulation (imbalance between reactive oxygen species (ROS) production and antioxidants) and neuroinflammation, contributing to an imbalance between inhibitory and excitatory neurotransmitters, an imbalance which is involved in the pathophysiology of schizophrenia [63]. Here, AGER is linked to schizophrenia.