Specifically, in knock-in mice models with F121A point mutation in BECN1, a cross of these F121A BECN1 with 5xFAD and platelet-derived growth factor promoter driving expression of human amyloid precursor protein (PDAPP) mice was used to study the effects of autophagy hyperactivation on AD pathology [86,87]. This evidence concerns the gene APP and Alzheimer disease.