For instance, ERα has been implicated in mediating E2’s anti-inflammatory effects in the brain [66] and in providing protection against strokes in both male and female mice [65], while ERβ supports learning and memory in the postmenopausal models of AD by maintaining mitochondrial homeostasis through NRF1/PGC-1α signaling [61]. The gene discussed is PPARGC1A; the disease is Alzheimer disease.