PTGS2 and neoplasm: The suppression of the growth rate was reversed when COX-2 knockout cells were co-cultured with bone marrow-derived MC (2.0 ± 0.7) or Mφ (1.8 ± 0.7) cells (*** p < 0.001) (Figure 3b, right panel), This suggests a critical role for infiltrating immune cells in modulating tumor growth compared to U87wt co-cultured with MCs or Mφs (Figure 3b, left panel).