Antibody array analysis reveals an upregulation of apoptosis-related proteins (e.g., MAPK15 and p53) and downregulation of tumor–TME crosstalk markers (e.g., Il-10, CXCL2, and E-Selectin) in COX-2 knockout cells (Figure 1c). The gene discussed is CXCL2; the disease is neoplasm.