Noteworthy is the selective cytotoxicity of azurin: it appears to be associated with preferential entry into tumor cells, induction of apoptosis via mitochondrial pathways, which our in silico docking simulations support by predicting a stable and energetically favorable complex with the p53 protein, and increased expression of proapoptotic genes while decreasing expression of anti-apoptotic genes and corresponding protein levels. This evidence concerns the gene TP53 and neoplasm.