CXCL8 and colorectal carcinoma: This study aimed to assess the impact of betulin and its two synthetic derivatives, EB5 (28-propynoylbetulin) and ECH147 (29-diethoxyphosphoryl-28-propynoylbetulin), on CXCL8 expression at both the mRNA and protein levels in CRC cell lines SW1116, HT-29, and RKO.